在多重内分泌新陈代谢1型综合征中的复发性原发性甲状腺功能障碍
P Libánský1, J Čarková, I Kushnir
13rd Department of Surgery, 1st Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic. petr.libansky@lf1.cuni.cz.
Physiological research
|December 20, 2023
概括
患有多发性内分泌新陈代谢1型 (MEN1) 综合征的患者有更高的风险需要为原发性副甲状腺功能障碍重新手术. 早期基因检测可以改善这些人的手术规划和结果.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
- 手术瘤学手术瘤学
背景情况:
- 原发性甲状腺功能障碍是一种普遍存在的内分泌疾病.
- 多发性内分泌新陈代谢1型 (MEN1) 是一种罕见的遗传综合征,易患内分泌瘤,包括原发性副甲状腺功能障碍.
- 原发性甲状腺功能障碍症的复手率可能是显著的.
研究的目的:
- 评估原发性副甲状腺功能障碍症患者的重新手术率.
- 为了确定MEN1综合征是否会影响这些患者重新手术的需要.
- 强调手术前识别MEN1综合征的重要性.
主要方法:
- 在2018-2022年期间,对1011名因原发性副甲状腺功能障碍而接受手术的患者进行了回顾性分析.
- 在队列中识别患有MEN1综合征的患者.
- 在MEN1患者和一般的原发性甲状腺功能障碍症队列之间,重新手术的比较率.
主要成果:
- 整体重复手术率为8% (78名患者).
- 27名患者 (2.7%的总队列) 患有MEN1综合征.
- 35% (共27名) 的MEN1患者需要重新手术,明显高于一般队列.
- 患有MEN1综合征的患者显示需要重新手术的风险更高.
结论:
- MEN1综合征与原发性副甲状腺功能障碍症的重新手术风险增加有关.
- 针对MEN1综合征进行手术前遗传检测对于风险分层至关重要.
- 对于MEN1患者来说,需要明智的外科手术方法,以尽量减少重复手术.
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