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Updated: Jul 8, 2025

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
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CD40/CD40连接物二及其下游的效应分子ISG54能够将急性神经炎症与持续的,渐进的脱髓化相关联

Bishal Hazra1, Jayasri Das Sarma1,2

  • 1Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, India.

IUBMB life
|December 20, 2023
PubMed
概括

这项研究调查了多发性硬化症 (MS) 的病毒性原因,研究了小鼠肝炎病毒 (MHV-A59) 如何诱导神经炎症和脱髓化. 它强调了CD40-CD40L和干扰素刺激基因 (ISG) 在这种实验性MS模型中的作用.

关键词:
在CD40-CD40L二中.如果it2如果it2如果it2在MHV-A59/RSA59中使用.在MSMSMSMSMSMSMSMSMSMSMS中,我们可以看到脱化是脱化的一种.原生和适应性免疫反应.干扰素刺激的基因是干扰素刺激的基因.

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