在早产的成年人中,大脑血管CO2反应在高海拔处受损
Giorgio Manferdelli1, Benjamin J Narang2,3, Nicolas Bourdillon1
1Institute of Sport Sciences, University of Lausanne, Lausanne, Switzerland.
The Journal of physiology
|December 20, 2023
概括
高海拔暴露显示,早产成人的脑血管反应受损,与早产成年人不同. 这表明,在高海拔地区的早产儿中,大脑血流调节受损,可能会增加他们患高海拔相关疾病的风险.
科学领域:
- 生理学 生理学 生理学
- 高度医学 高度医学
- 神经学 神经学
背景情况:
- 过早分娩会影响心脏和呼吸系统对低氧和高头的反应.
- 在高海拔地区早产的个体中,大脑血管反应在很大程度上仍然没有特征.
- 了解这些反应对于评估与高度相关的健康风险至关重要.
研究的目的:
- 在早产的成年人中研究大脑血管对高海拔高度的超和低的反应.
- 为了比较早产和满产成年人之间的这些反应.
- 为了确定高空暴露是否揭露大脑血管调节的差异.
主要方法:
- 在海平面和高海拔 (3375米) 上研究了16名早产儿和15名满产儿.
- 参与者接受了高氧性高头 (3%和6%的CO2) 和自愿的高通风诱导的低头.
- 测量了中脑动脉的血液速度,潮尾CO2,通风和血液气体.
主要成果:
- 满期出生的成年人显示出基线中脑动脉血速增加和高海拔地区更高的低脑血管反应.
- 过早出生的成年人没有表现出在海拔高度基础血液速度的增加,并且已经改变了超体反应能力.
- 在高海拔地区,与早产的成年人相比,按期出生的成年人具有较高的低和较低的高二氧化碳反应能力.
结论:
- 急性高空暴露显示了早产儿和早产儿之间明显的脑血管反应.
- 在高海拔地区,早产的成年人表现出脑血管扩张反应,脑血流的调节受损.
- 这些发现表明,早产儿对高海拔地区疾病的敏感性可能会增加.
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