在PI3K/AKT基因中的多态性和基因吸烟相互作用与对结核病的易感性有关
Chunli Wu1, Huixia Liu1, Ying Lin1
1Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Annals of human biology
|December 20, 2023
概括
PI3K/AKT通路基因的遗传变异,特别是PI3KR1和AKT1,与结核病 (TB) 易感性有关. 吸烟与这些遗传因素相互作用,增加结核病风险.
科学领域:
- 遗传学 遗传学 是一个
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 酸丁醇3-酶 (PI3K) 和蛋白酶B (AKT) 信号通路在巨细胞介导的Mycobacterium tuberculosis (MTB) 清除中发挥着至关重要的作用.
- 这一途径中的遗传变异可能会影响一个人患结核病 (TB) 的易感性.
研究的目的:
- 研究PI3K/AKT通路基因中的多态性与患结核病的风险之间的关联.
- 检查影响结核病易感性的潜在基因吸烟相互作用.
主要方法:
- 一项涉及503名结核病患者和494名健康对照者的病例控制研究.
- 在PI3KR1 (rs3730089) 和AKT1 (rs1130233) 基因中特定多态的基因定型.
- 后勤回归和边缘结构线性主导模型被用来分析遗传关联和基因吸烟相互作用.
主要成果:
- 在PI3KR1 (GA,AA) 中的rs3730089和AKT1 (AG,GG) 中的rs1130233的特定基因型与结核病风险增加有显著的关联.
- 在rs3730089多态和吸烟之间观察到一种积极的相互作用 (RERI = 0.9608,p < 0.05),表明吸烟者具有这种基因型的个体对结核病的易感性增加.
结论:
- 在PI3KR1 (rs3730089) 和AKT1 (rs1130233) 中的多态性是结核病易感性的重要遗传风险因素.
- 有一个显著的基因吸烟相互作用存在,吸烟加剧了携带 rs3730089 变种的个体患结核病的风险.
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