马类皮肤炎的爆发与帕拉波克斯病毒相关
Jenni Virtanen1,2, Katja Hautala1, Mira Utriainen2
1Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
The Journal of general virology
|December 20, 2023
概括
马类帕洛克斯病毒 (EqPPV) 在芬兰引起了一次大型马皮肤炎疫情. 该病毒的遗传变异很小,可能在马和人类之间传播,赛马是关键的危险因素.
科学领域:
- 兽医病毒学 兽医病毒学
- 皮肤病学 皮肤病学
- 流行病学 流行病学
背景情况:
- 众所周知,帕拉波克斯病毒 (PPV) 引起动物性皮肤病变.
- 马类帕拉波克病毒 (EqPPV) 之前在人类和马匹中被发现.
- 在芬兰马匹中发生了一次显著的 pustulo-vesicular pastern dermatitis 疫情.
研究的目的:
- 分析芬兰2021年至2022年的EqPPV疫情.
- 确定致病原体并描述临床症状.
- 调查风险因素和潜在的动物传播.
主要方法:
- 对受影响和对照稳定的流行病学调查.
- 使用新型诊断PCR识别EqPPV.
- 从临床样本中对病毒的基因组测序.
- 皮肤病变的组织病理学检查.
主要成果:
- EqPPV被确定为疫情的可能原因.
- 观察到与致病性细菌的同时感染.
- 开发了一个高度敏感的EqPPV特定的PCR.
- 在历史和最近的EqPPV菌株之间发现了最小的遗传变异.
- 赛马被确定为主要的危险因素.
- 临床皮肤炎影响了疫情稳定的三分之一左右的马.
- 报道了人类皮肤病变,这表明动物感染的潜力.
结论:
- EqPPV是芬兰大型马匹皮肤炎疫情的致病原体.
- 该病毒具有较低的遗传变异性和潜在的动物传播.
- 拥有赛马是一个重要的风险因素.
- 需要对未来的疫情进行更好的诊断和准备.
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