在儿童和青少年中治疗狼性炎
Eugene Yu-Hin Chan1,2, Fiona Fung-Yee Lai3, Alison Lap-Tak Ma3,4
1Paediatric Nephrology Centre, Hong Kong Children's Hospital, Kowloon, Hong Kong. genegene.chan@gmail.com.
Paediatric drugs
|December 20, 2023
概括
儿童开始的狼性炎 (LN) 影响35-60%的儿科系统性红斑狼患者,导致功能衰竭. 本综述详细介绍了儿科LN的不断发展的管理,考虑到独特的疾病和心理社会方面.
科学领域:
- 儿科脏病学 儿科脏病学
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 狼性炎 (LN) 是系统性红斑狼 (SLE) 的严重并发症,经常导致慢性病和死亡.
- 儿科SLE患者的LN发病率高 (35-60%),影响长期健康结果.
- 尽管治疗进展,但高水平的证据管理儿童发病的LN是有限的,由于小患者队列和试验排除.
研究的目的:
- 审查儿童发作狼性炎的当前管理策略.
- 要突出与成人发病疾病相比,儿科LN的不同临床,治疗和心理社会考虑.
- 提供关于管理儿科LN的"艺术和科学"的最新视角.
主要方法:
- 关于儿童发作狼性炎现有文献的综述.
- 分析儿科和成人患者之间疾病表现,治疗反应和耐受性的差异.
- 目前临床管理指南和新兴治疗方法的综合.
主要成果:
- 由于免疫抑制疗法和更好的临床管理,LN患者的结果有所改善.
- 儿童和成年期LN之间存在显著的差异,涉及疾病严重程度,治疗疗效,药物耐受性和心理社会影响.
- 管理需要量身定制的方法,考虑到儿童和青少年独特的发育和生理方面.
结论:
- 管理童年发病的狼性炎需要专业知识超出成人协议.
- 解决儿科患者独特的疾病特征和心理社会需求对于最佳结果至关重要.
- 持续的研究和儿科特定的临床试验对于推进基于证据的儿童LN护理至关重要.
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