与MDPHP摄入相关的严重25E-NBOH中毒:一个病例报告,代谢研究和文献综述
Romain Pelletier1,2, Thomas Gicquel3,4, Julien Carvelli5
1INSERM, INRAE, CHU Rennes, Institut NuMeCan (Nutrition, Metabolism and Cancer), PREVITOX Network, F-35033, Rennes, France. romain.pelletier@chu-rennes.fr.
International journal of legal medicine
|December 20, 2023
概括
一名男子在摄入一种被销售为25I-NBOH的物质后经历了严重的反应. 分析显示25E-NBOH和MDPHP,25E-NBOH代谢物被确定为潜在的中毒标志物.
科学领域:
- 法医毒理学 法医毒理学
- 药理学 药理学是指药理学的学科.
- 分析化学 分析化学
背景情况:
- N-基乙胺衍生物,如NBOMe和NBOH,已知是具有幻觉效应的5-HT2A受体激活剂.
- 这项研究详细介绍了一个23岁的男性病例,他在摄入了一种被误认为25I-NBOH的粉末后出现了血清激素综合征和意识丧失.
研究的目的:
- 为了确定导致患者症状的物质.
- 在真实的生物样本中进行第一个25E-NBOH代谢研究.
- 为了确定25E-NBOH消费的潜在生物标志物.
主要方法:
- 液体染色学高分辨率质谱法 (LC-HRMS) 用于对血和尿液样本的毒理分析.
- 使用经过认证的参考材料来确认检测到的物质的身份.
- 在代谢研究中使用了分子网络.
主要成果:
- 粉末中含有25E-NBOH和MDPHP,而不是25I-NBOH. 在血和尿液中量化了25E-NBOH和MDPHP的度.
- 确定了25E-NBOH (M1-M7) 的七种代谢物,包括两种I期代谢物和五种II期代谢物.
- 代谢物M6 (m/z 492.223) 是最强的离子,被提议作为25E-NBOH消耗的潜在标记物.
结论:
- 本报告介绍了25E-NBOH中毒的原始病例.
- 已识别的代谢物,特别是M6,可以作为可靠的标志物来检测25E-NBOH中毒,以提高信心和潜在的更长的检测窗口.
- 这些发现有助于理解新型精神活性物质毒性和分析.
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