Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Mitochondrial Dynamic Proteins MiD49 and MiD51 as Novel Targets of Cardioprotection.

Cells·2026
Same author

An activator of phosphatidylinositol 3-kinase alpha restores cardioprotection from ischaemia/reperfusion injury in mice with coronary atherosclerosis or insulin resistance.

Cardiovascular research·2025
Same author

The contribution of cardiomyocyte hypercontracture to the burden of acute myocardial infarction: an update.

Basic research in cardiology·2025
Same author

Novel Selective Cardiac Myosin-Targeted Inhibitors Alleviate Myocardial Ischaemia-Reperfusion Injury.

Cardiovascular drugs and therapy·2025
Same author

SGLT2 Inhibition Induces Cardioprotection by Increasing Parasympathetic Activity.

Circulation research·2024
Same author

Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop.

Basic research in cardiology·2024

相关实验视频

Updated: Jul 8, 2025

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
07:52

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

12.0K

远程缺血调节在老鼠中的心脏病限制效果不受阿司匹林的影响.

M V Basalay1, James M Downey2, S M Davidson1

  • 1The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX, UK.

Cardiovascular drugs and therapy
|December 20, 2023
PubMed
概括

远程缺血调节 (RIC) 在动物模型中保护心脏. 这项研究发现,阿司匹林在心肌梗塞恢复期间不会阻止RIC的心脏保护作用.

关键词:
阿司匹林是一种阿司匹林.缺血/再输液损伤 缺血/再输液损伤远程调节条件 远程调节条件

更多相关视频

Focal Cerebral Ischemia Model by Endovascular Suture Occlusion of the Middle Cerebral Artery in the Rat
13:50

Focal Cerebral Ischemia Model by Endovascular Suture Occlusion of the Middle Cerebral Artery in the Rat

Published on: February 5, 2011

79.8K
Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
07:46

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia

Published on: May 9, 2013

29.2K

相关实验视频

Last Updated: Jul 8, 2025

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
07:52

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

12.0K
Focal Cerebral Ischemia Model by Endovascular Suture Occlusion of the Middle Cerebral Artery in the Rat
13:50

Focal Cerebral Ischemia Model by Endovascular Suture Occlusion of the Middle Cerebral Artery in the Rat

Published on: February 5, 2011

79.8K
Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
07:46

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia

Published on: May 9, 2013

29.2K

科学领域:

  • 心血管研究研究心血管研究
  • 药理学 药理学是指药理学的学科.
  • 缺血性调节 缺血性调节

背景情况:

  • 远程缺血调节 (RIC) 在临床前研究中显示出心脏保护潜力.
  • 对RIC在急性心肌梗塞 (AMI) 的疗效的临床证据不一致.
  • 阿司匹林通常用于再注射疗法,可能会干扰心脏保护策略.

研究的目的:

  • 为了研究阿司匹林是否阻断了RIC在肌肉心脏梗塞的老鼠模型中限制心脏病发作的影响.
  • 为了确定阿司匹林和RIC之间的相互作用,在重灌损伤的背景下.

主要方法:

  • 雄性Sprague Dawley大鼠接受了30分钟的心肌缺血,随后进行了120分钟的再注射.
  • 在20分钟的心肌缺血后,应用了RIC协议 (四个5分钟后肢缺血/再输液周期).
  • 阿司匹林 (30 mg/kg IV) 或载体是在15分钟心肌缺血后给药的.

主要成果:

  • 与风险区域相比,RIC显著减少了47%的心脏病发作大小.
  • 服用阿司匹林并没有改变心脏病发作的大小.
  • 阿司匹林没有减弱RIC的心脏病抑制作用.

结论:

  • 在心肌梗塞患者中,阿司匹林不太可能干扰RIC的心脏保护作用.
  • 在AMI期间,RIC仍然是一个潜在的治疗策略,以限制心脏病发作的大小,独立于阿司匹林的使用.