感染性内心炎抗生素预防:证据和指导方针的审查
Mia M Pries-Heje1,2, Henning Bundgaard1,3, Kasper K Iversen3,4
1Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Current cardiology reports
|December 20, 2023
概括
感染性内心炎 (IE) 的抗生素预防仍然存在争议. 目前主要协会的指导方针不同,支持建议的证据是相互矛盾的,使最佳方法变得不确定.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素预防预防感染性内心炎 (IE) 的作用是一个正在进行的辩论的主题.
- 来自AHA,ESC和NICE等组织的国际指南提出了不同的建议.
- 对IE抗生素预防的既定指南的遵守一直不一致.
研究的目的:
- 为了比较和对比AHA,ESC和NICE对IE的当前抗生素预防建议.
- 检查支持这些国际指南的证据基础.
- 要突出围绕IE抗生素预防的争议和不确定性.
主要方法:
- 对IE抗生素预防的当前国际指南 (AHA,ESC,NICE) 的比较分析.
- 审查现有的文献和证据支持指导方针建议.
- 评估检查预防指导方针的遵守和影响的研究.
主要成果:
- 自2009年以来,IE抗生素预防的国际准则发生了有限的变化.
- 研究表明,关于更严格的预防建议的影响,研究结果相互矛盾.
- 经常观察到人们不遵守当前的ESC,NICE和AHA指南.
结论:
- 对于IE的抗生素预防问题仍然存在争议,因为国际建议有所不同.
- 来自观察研究的相互矛盾的证据和缺乏随机试验有助于不确定性.
- 对IE的最佳抗生素预防策略仍然在很大程度上基于专家的共识,而不是最终的证据.
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