腰围和女性不孕症之间的关联在美国
Jierong Ke1, Yuntian Feng2, Zhiyun Chen1
1Center for Reproductive Medicine, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
PloS one
|December 20, 2023
概括
增加的腰围 (WC) 与女性不孕症风险更高有关,独立于BMI. 适度的娱乐活动可以减轻与腹部肥胖相关的风险.
科学领域:
- 生殖健康 生殖健康
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 肥胖是影响生育能力的一个已知的因素.
- 专门将腹部肥胖与女性不孕症联系在一起的证据有限.
- 腰围 (WC) 是腹部肥胖的一个关键指标.
研究的目的:
- 调查 WC 与美国生育年龄女性不孕症之间的关系.
- 为了确定腹部肥胖,通过WC测量,是女性不孕症的独立风险因素.
- 分析休活动水平对WC-不孕症协会的影响.
主要方法:
- 使用NHANES数据对3239名年龄在18-45岁的女性进行横截面研究.
- 权重多变量后勤回归来评估WC与不孕不育之间的独立关联.
- 调整曲线适配,相互作用和子组分析,以探索剂量依赖和活动相关的关系.
主要成果:
- WC显示出与女性不孕症有显著的积极关联,独立于BMI.
- 每增加1厘米的WC与不孕症风险增加3%相关 (OR=1.03).
- 与最低五分之一 (OR=2.64) 相比,WC五分之一中最高的女性患不孕的风险是2.64倍.
- 在WC和不孕症之间观察到非线性,剂量依赖的关系.
- 娱乐活动改变了WC与不孕症的关系,显示了反转的U形 (中度活动) 和J形 (缺乏活动) 模式.
结论:
- 腰围是女性不孕症的重要预测因素,不管BMI如何.
- 腹部肥胖,由WC表示,增加不孕症的风险.
- 适度的娱乐活动可以降低与腹部肥胖相关的不孕症风险.
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