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Updated: Jun 16, 2026

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
11:10

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3

Published on: December 27, 2010

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使用病毒序列多样性来估计婴儿感染艾滋病毒的时间

Magdalena L Russell1,2, Carolyn S Fish3, Sara Drescher4,5

  • 1Computational Biology Program, Fred Hutch Cancer Center, Seattle, Washington, United States of America.

PLoS pathogens
|December 20, 2023
PubMed
概括

准确确定婴儿HIV感染时间至关重要. 在婴儿数据上训练的新模型显示比成人模型更快的病毒多样性积累,改善了感染时间估计.

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Pairwise Growth Competition Assay for Determining the Replication Fitness of Human Immunodeficiency Viruses11:19

Pairwise Growth Competition Assay for Determining the Replication Fitness of Human Immunodeficiency Viruses

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Determining 3'-Termini and Sequences of Nascent Single-Stranded Viral DNA Molecules during HIV-1 Reverse Transcription in Infected Cells13:07

Determining 3'-Termini and Sequences of Nascent Single-Stranded Viral DNA Molecules during HIV-1 Reverse Transcription in Infected Cells

Published on: January 30, 2019

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相关概念视频

Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...