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Updated: Jul 8, 2025

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
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慢性间歇性乙醇暴露引起的m6A在mRNA周围的修饰,阻止了阿片类受体基因的片

Ying Liu1,2, Ji Sun Koo3, Huiping Zhang1,2

  • 1Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, USA.

Epigenetics
|December 20, 2023
PubMed
概括

长期暴露于酒精会改变全球RNA甲基化,并降低大脑细胞中的阿片类受体基因表达. 这表明一种表观转录机制有助于酒精使用障碍的风险.

关键词:
腺癌细胞系SW62020的细胞系SW620全球m6ARNA甲基化在MazF-RT-qPCR和RT-qPCR中使用.慢性间歇性乙醇 (CIE) 暴露神经母细胞瘤细胞系SH-SY5YY其他阿片类受体基因 (OPRM1,OPRD1和OPRK1)停止编码区m6ARNA甲基化

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