基于综合数据的不利结果路径框架的构建,以评估引起的非酒精性脂肪肝疾病

Bowen Fan1, Cheng Cheng1, Yi Yang1

  • 1Center for Global Health, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Suzhou Institute of Public Health, Gusu School, Nanjing Medical University, Nanjing 211166, Jiangsu, People's Republic of China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, People's Republic of China.

Environment international
|December 20, 2023
PubMed
概括

环境暴露与非酒精性脂肪性肝病 (NAFLD) 有关. 这项研究使用了不良结果途径 (AOP) 来揭示机制,确定TNF-α和NF-κB是引起的肝损伤的关键参与者.