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Mio Kobayashi Frisk¹, Erika Fagman², Daniel Arvidsson³

¹University of Gothenburg, Institute of Medicine, Center for Sleep and Vigilance Disorders, Gothenburg, Sweden.

|December 20, 2023

概括

极端晚间时间型的人患冠状动脉化 (CAC) 的患病率更高,这是动脉样硬化的一个标志. 这些发现表明昼夜因素影响心血管疾病风险.

科学领域:

心血管成像和诊断系统
时间生物学和睡眠医学
预防性心脏病学预防性心脏病学

背景情况:

冠状动脉化 (CAC) 是亚临床动脉样硬化的关键指标.
白天偏好 (时间型) 和CAC之间的关系还不太清楚.
了解这种联系可能为预防心血管疾病提供新的途径.

研究的目的:

调查时间型与冠状动脉化 (CAC) 患病率之间的关联.
探索是否时间型影响基于CAC的心血管风险分层.
检查昼夜因素在动脉样硬化的发展中的作用.

主要方法:

从瑞典心肺生物图像研究 (SCAPIS) 试点队伍中对771名参与者 (50-64岁) 的横截面分析.
通过非对比计算机断层扫描评估CAC;显著化定义为CAC得分>10.
使用自我评估的白天偏好进行分类的年代型;使用系统冠状动脉风险评估2 (SCORE2) 估计的心血管风险.

主要成果:

在队列中观察到29%的显著CAC患病率.
从极端的早晨到极端的晚上时长类型 (22%到41%) 的CAC患病率增加了.
与极端的早晨类型相比,极端的晚上类型独立地与增加的CAC患病率 (OR 1.90) 相关.
极端的晚间时间型显示,在低至中等心血管风险组中,CAC患病率最高.

结论:

时间型,特别是极端的晚上偏好,与冠状动脉化的更高患病率有关.
循环的因素可能在动脉样硬化的发病过程中发挥重要作用.
在早期心血管疾病预防策略中应考虑时代型.

关键词:

测速加速仪的使用方法动脉样硬化是一种动脉样硬化.心血管疾病的风险.时间型时间型时间型循环节律的破坏.基于人口的基础上.预防预防预防这就是Score2的原因.社会经济地位社会经济地位

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