血液风病学和血液动力学
Oguz K Baskurt1, Herbert J Meiselman2
1Department of Physiology, Akdeniz University Faculty of Medicine, Antalya, Türkiye.
Seminars in thrombosis and hemostasis
|December 20, 2023
概括
血液粘度取决于红细胞 (RBC) 的特性和聚合,这对血液流动至关重要. 这些因素的变化会损害组织输液,并导致各种疾病的功能恶化.
科学领域:
- 血液学和血液学:专注于血液的物理特性及其临床含义.
- *心血管生理学:探索血液流动动力学和组织 perfusion.
背景情况:
- *血液是一种非牛顿流体,其表面粘度取决于切削力,血红素,血粘度,红细胞聚合和红细胞机械特性.
- *红细胞变形性对血液流动至关重要,特别是在微循环中,受膜性质,细胞形态和细胞质粘度的影响.
- *红细胞聚合,一个受剪切力影响的可逆过程,显著影响血液流动性,特别是在低流量条件下.
研究的目的:
- * 为了突出最多引用的论文在 * 血栓形成和血液静止的研讨会 * (STH) 关于血液类风湿学.
- *审查血液粘度的决定因素,包括血红素,血粘度,红细胞聚合和红细胞机械性质.
- *讨论在各种生理病理条件下改变血液风湿学的影响.
主要方法:
- * 血液风病学及其决定因素的基本原则的综述.
- * 分析影响红细胞 (RBC) 变形和聚合的因素.
- * 检查血液风湿学与疾病状态之间的关系.
主要成果:
- *血液粘度是细胞和血因素的复杂相互作用,红细胞可变性和聚合是关键决定因素.
- * 变化的血红素,红细胞变形能力受损 (由于遗传性疾病或环境因素),以及红细胞聚合增加 (通常与炎症有关) 显著影响血液流动性.
- * 血液类风学变化可能导致组织输液受损和功能恶化,特别是当血管特性也受到损害时.
结论:
- *了解血液类风病学,特别是红细胞的行为,对于理解正常生理学和病理生理学至关重要.
- *血液粘度的偏差,由诸如改变红细胞聚合和变形能力等因素驱动,与各种疾病过程有关.
- * 血液流动性受损对组织输液和器官功能构成重大风险.
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