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血小板功能测试和外围动脉疾病的临床结果:系统性审查和叙述综合
Aman Kankaria1, Monica Majumdar2, Sonia Lee3
1School of Medicine and Biosciences, Kansas City University, Kansas City, MO.
Journal of vascular surgery
|December 20, 2023
概括
血小板功能检测 (PFT) 可以检测周围动脉疾病 (PAD) 患者在再血管化后的抗血小板耐药性. 这有助于预测并发症和量身定制治疗,尽管需要标准化的方法.
科学领域:
- 血管外科 血管外科
- 药理学 药理学是指药理学的学科.
- 临床诊断 临床诊断 临床诊断
背景情况:
- 周围动脉疾病 (PAD) 的管理往往涉及到重血管化程序.
- 抗血小板治疗对于预防血栓事件至关重要.
- 评估个体患者对抗血小板药物的反应具有临床意义.
研究的目的:
- 系统地审查目前关于在PAD患者进行重血管化的血小板功能测试 (PFT) 的文献.
- 评估PFT检测抗血小板抵抗和预测并发症的能力.
- 探索PFT在定制抗血小板治疗策略中的作用.
主要方法:
- 按照PRISMA指南进行系统的文献审查.
- 在PubMed上使用相关的医学主题标题 (MeSH) 术语进行的搜索.
- 包括在1990-2023年间发表的研究,研究了下肢再血管化后PAD患者的PFT.
主要成果:
- 十项研究符合纳入标准,采用了各种PFT方法 (例如,血栓显微镜,VerifyNow,聚合计).
- PFT确定了抗血小板耐药性的患者,与移植/支架血栓形成,截肢和重新干预的风险更高相关.
- 在各项研究中,在手术技术,抗血小板疗法和PFT方法学方面注意到了显著的异质性.
结论:
- 血小板功能测试对于检测PAD患者的抗血小板耐药性是有价值的.
- PFT方法和数据的异质性需要标准化和共识,以提高临床效用.
- 需要进行进一步的研究,以确定PFT在指导抗血小板治疗和优化血管外科手术的结果方面发挥的决定性作用.
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