怀孕期间母亲的压力生活事件以及儿童喘和喘息
Margaret A Adgent1, Erin Buth2, Amanda Noroña-Zhou3
1Department of Health Policy, Vanderbilt University Medical Center, Nashville, TN.
产前母亲的压力增加了儿童喘息风险,特别是在男孩中. 这项研究研究了可能改变这些风险的因素,发现儿童的性别显著影响了喘的结果.
科学领域:
- 环境健康 环境健康
- 儿科呼吸系统健康 儿科呼吸系统健康
- 生殖流行病学 生殖流行病学
背景情况:
- 产前母亲的心理社会压力与童年喘息和喘有关.
- 缓解这些风险的因素尚不清楚.
研究的目的:
- 调查产前压力与儿童喘息/喘之间的关联.
- 评估可能改变产前压力对呼吸系统结果影响的因素.
主要方法:
- 利用了来自3个潜在怀孕队伍 (ECHO-PATHWAYS) 的2056个母婴二极管的数据.
- 通过使用标准化问卷来评估怀孕期间母亲的压力生活事件 (PSLEs).
- 儿童喘息/喘结局 (曾经的喘,目前的喘息,目前的喘,严格的喘) 在4-6岁时被报告.
- 修改Poisson回归估计风险比率 (RRs) 对于PSLEs,调整以考虑混因素.
- 根据孩子的性别,母亲喘病史,童年创伤,社区资源和母乳养的评估效果修改.
主要成果:
- 增加的PSLE与较高的当前喘息风险显著相关 (RR,1.09).
- 在严格的喘中观察到儿童性别的显著效果修饰,男孩的风险增加 (RR, 1.10).
- 虽然其他结果的风险在男孩中普遍较高,但对效果修改的统计学意义并不总是得到满足.
结论:
- 增加产前母亲的压力生活事件与儿童呼吸系统不良结果有关.
- 儿童的性别是一个重要的改变因素,男孩对某些喘结果的风险更高.
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