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Updated: Jul 7, 2025

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
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Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Published on: September 12, 2019

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开发一种基于MRI的预测模型,用于对TNF治疗在Perianal Crohn's病中的失败:一个多中心研究

Jeffrey D McCurdy1, Javeria Munir2, Simon Parlow3

  • 1Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
|December 20, 2023
PubMed
概括

这项研究使用临床和MRI数据开发了预测模型,以识别与克罗恩氏病相关的近囊 (PAF) 患者,可能经历抗瘤缩因子 (TNF) 治疗失败. 这些模型准确地预测治疗结果.

关键词:
IBD并发症 IBD并发症周围的克罗恩氏病.预测模型的预测模型

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A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease05:08

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Pharmacologic...
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