多组学被用来澄清空气污染物影响慢性阻塞性肺病的机制:人类队列研究
Huijun Li1, Yanting Yang1, Yanpeiyue Yang1
1School of Public Health, Xinxiang Medical University, Xinxiang, Henan 453003, China.
空气污染,特别是PM2.5,对肠道微生物群多样性产生负面影响,并改变慢性阻塞性肺病 (AECOPD) 急性恶化患者的新陈代谢. 这项研究揭示了关键的生物标志物,将空气质量与AECOPD联系起来,帮助精确的预防策略.
科学领域:
- 环境健康 环境健康
- 微生物组研究 微生物组研究
- 代谢学 代谢学 代谢学
背景情况:
- 暴露于空气污染物与不良健康结果有关,包括慢性阻塞性肺病 (COPD).
- 空气污染影响COPD的确切机制尚不清楚.
- 了解由于空气污染而导致的AECOPD患者的肠道微生物组和代谢变化至关重要.
研究的目的:
- 阐明分子机制,将空气污染物暴露与肠道微生物群和AECOPD患者的代谢变化联系起来.
- 确定与空气污染暴露相关的生物标志物和AECOPD.
- 探索精确预防COPD的潜在途径.
主要方法:
- 甲基因组学和非向代谢学被用来分析肠道微生物,便和血清代谢物.
- 综合添加混合模型和斯皮尔曼相关性分析被用来评估相关性.
- 分析包括空气污染物,肠道微生物,血清代谢物和血液生物化学标记物.
主要成果:
- 增加10μg/m3的PM2.5度与肠道菌群α-多样性下降2.16%相关.
- 包括Enterococcus faecium和Bacteroides fragilis在内的7种微生物与空气污染物有显著的关联,并且与糖解有关.
- 13种血清和17种便代谢物与空气污染物有显著联系,其中7种在两种样本类型中都被发现,并与脂质/脂肪酸代谢障碍相关.
结论:
- 空气污染物对AECOPD患者的肠道微生物群和新陈代谢产生重大影响.
- 改变的微生物和代谢生物标志物在空气污染暴露和AECOPD之间建立了生物学联系.
- 已识别的生物标志物为开发精确的COPD预防策略提供了洞察力.
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