在自闭症谱系障碍中微生物群-肠道-大脑轴的许多面孔
Cinara L Gonçalves1, Tejaswini Doifode2, Victoria L Rezende1
1Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
Life sciences
|December 20, 2023
概括
肠道微生物组对自闭症谱系障碍 (ASD) 中的大脑产生影响. 基于微生物群的治疗方法,如益生菌和饮食变化,显示出对管理ASD症状的希望.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 遗传学 是一个遗传学.
背景情况:
- 人们越来越认识到肠-大脑轴在神经发育障碍,特别是自闭症谱系障碍 (ASD) 中的作用.
- 早期生活因素显著影响肠道微生物群的组成,影响宿主遗传和围产期事件.
- 肠道微生物组的改变会影响血脑屏障的完整性,药物的有效性和社会行为.
研究的目的:
- 审查当前对肠道微生物群对自闭症谱系障碍 (ASD) 的影响的理解.
- 探索基于微生物群的干预措施治疗ASD的潜力.
- 确定ASD肠-大脑轴研究的研究缺口和未来方向.
主要方法:
- 文献综述侧重于肠-大脑轴和ASD.
- 对影响早期肠道微生物群的因素的分析.
- 讨论先进的"omics"技术 (RNA测序,代谢学,转录学) 以获得机械的见解.
主要成果:
- 肠道微生物群通过影响血脑屏障和宿主行为,在ASD病理生理学中发挥作用.
- 基于微生物群的干预措施,如益生菌,便微生物群移植和代谢物补充是潜在的治疗途径.
- 在ASD中显著的临床异质性表明需要个性化治疗方法.
结论:
- 饮食调节与微生物群调节剂相结合,为ASD症状提供了一个有希望的策略.
- 进一步的研究对于开发准确的生物标志物测试和针对ASD的有针对性的精神病菌剂至关重要.
- 针对ASD患者特定肠道微生物群特征量身定制的个性化治疗选择是未来的关键方向.
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