不仅仅是一个简单的发作障碍:及其并发症之间的因果关系
Saskia I Peek1, Friederike Twele1, Sebastian Meller1
1Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Germany.
Veterinary journal (London, England : 1997)
|December 20, 2023
概括
狗与认知障碍 (CI) 和注意力缺陷多动症障碍 (ADHD) 类似的行为有共同的病理途径. 大脑结构,神经传递和炎症将发作与这些狗的行为和认知并发症联系起来.
科学领域:
- 兽医神经学 兽医神经学
- 比较病理学比较病理学
- 神经科学是一个神经科学.
背景情况:
- 狗经常与认知障碍 (CI) 和注意力缺陷多动症障碍 (ADHD) 类似的行为,恐惧和焦虑同时发生.
- 狗和这些并发症之间的潜在病理机制和潜在因果关系尚未得到充分理解.
- 现有的对狗的研究是有限的,需要整合来自人类和实验室动物研究的发现.
研究的目的:
- 探索狗病原体及其常见的并发症之间的联系.
- 调查潜在的单向/双向因果关系和和相关认知和行为障碍的共同病因.
- 综合当前的知识,从人类和动物研究中得出结论,以阐明犬及其并发症之间的复杂关系.
主要方法:
- 文献综述综合了人类和实验室动物研究的信息,由于稀疏的犬类特定研究.
- 分析解剖结构,功能连接,神经传输中断和神经炎症过程.
- 检查功能性磁共振成像 (fMRI),间接性形放电 (IED) 和电脑图 (EEG) 研究的证据.
主要成果:
- 共享的解剖基质,特别是像杏仁体和海马体这样的边缘系统结构,都与发作和认知/行为障碍有关.
- 抑制性和刺激性神经递质的干扰会导致神经元过敏和网络功能障碍,导致和并发症.
- 神经炎症,氧化应激和线粒体功能障碍被确定为发作和情绪障碍的致病常见因素.
结论:
- 狗与认知障碍和行为并发症有着共同的病理生理基础.
- 杏仁体,海马体,神经递质失衡和神经炎症在发作和行为问题的共同发生中起着至关重要的作用.
- 了解这些复杂的相互关系对于管理犬及其相关疾病的综合方法至关重要.
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