评估睡眠架构和认知老年人的抑郁症状参加记忆诊所的老年人
Andrea Ricciardiello1, Andrew C McKinnon2, Loren Mowszowski2
1School of Psychology, Faculty of Science, University of Sydney, Camperdown, NSW, Australia; Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia; CIRUS, Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Macquarie University, Camperdown, NSW, Australia.
Journal of affective disorders
|December 20, 2023
概括
患有抑郁症的老年人表现出延迟的睡眠开始. 慢波睡眠 (SWS) 对抑郁者和非抑郁者的记忆有不同的影响,这表明SWS是潜在的认知功能的干预目标.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 睡眠医学 睡眠医学
背景情况:
- 老年人的抑郁症与睡眠障碍和认知变化有关.
- 晚期抑郁症中睡眠,认知和大脑完整性之间的具体相互作用仍然不清楚.
研究的目的:
- 为了研究睡眠模式,认知功能和老年人与没有抑郁症的大脑结构之间的关系.
- 探索抑郁和非抑郁的老年人之间睡眠结构和大脑完整性的差异,特别是那些患有晚期抑郁症的老年人.
主要方法:
- 来自记忆诊所的172名老年人 (66名抑郁症患者,106名对照患者) 接受了神经心理测试,核磁共振扫描和用定量EEG进行夜间多睡眠扫描.
- 评估声明性记忆,执行功能,海马体积,前额叶皮层厚度和睡眠参数,包括慢波睡眠 (SWS) 和REM睡眠.
主要成果:
- 两组之间没有发现SWS,REM睡眠持续时间,慢波活动,睡眠,海马体积或前额叶皮层厚度的显著差异.
- 与对照组相比,抑郁症组表现出较晚的睡眠开始延迟和REM开始延迟.
- 减少的SWS与抑郁症组的记忆力较差相关,但对照组的记忆力更好.
结论:
- 患有抑郁症状的老年人可能会经历延迟入睡,类似于延迟睡眠阶段.
- SWS与记忆之间的关联表明,SWS可能是抑郁症老年人认知干预的目标.
- 超出海马的神经网络可能是这群人睡眠和认知之间观察到的关联的基础.
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