在KORA研究中,长期暴露于环境空气污染和炎症反应
Megi Vogli1, Annette Peters2, Kathrin Wolf1
1Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
The Science of the total environment
|December 20, 2023
概括
长期暴露于空气污染物,包括超细颗粒 (UFP) 和细颗粒物 (PM2.5),与炎症和凝血生物标志物的增加有关. 这表明空气污染引起的心血管疾病风险更高.
科学领域:
- 环境健康 环境健康
- 心血管流行病学心血管流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 细颗粒物 (PM2.5) 与心血管疾病有关.
- 超细颗粒 (UFP) 对健康的不良影响越来越令人担忧,但长期研究有限.
研究的目的:
- 研究长期暴露于环境空气污染物和血液中炎症和凝血的生物标志物之间的关联.
- 评估UFP和PM2.5对特定生物标志物的影响,如纤维素,hs-CRP,SAA,皮蛋白和IL-6.
主要方法:
- 利用了德国KORA-S4队列研究 (1999-2001) 的数据.
- 使用土地利用回归模型估计的UFP,PM10,PM粗,PM2.5,PM2.5吸收率,O3,NO2和NOx的年平均度.
- 进行多重线性回归分析,调整混因子,以将污染物暴露与生物标志物水平联系起来.
主要成果:
- 增加的UFP暴露与更高的纤维素和hs-CRP水平相关.
- 在亚样本中,增加的PM2.5暴露与减少的阿迪波涅丁和升高的IL-6水平有关.
- 观察到的关联表明,由于空气污染物暴露,促炎和抗炎生物标志物发生了变化.
结论:
- 长期暴露于环境空气污染物,包括细颗粒和超细颗粒,与血液生物标志物的不良变化有关.
- 这些生物标志物变化与与慢性空气污染暴露有关的心血管疾病风险增加相一致.
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