[对社区人口中脂蛋白 (a) 度的5年趋势和影响因素的研究]
Y Q Zhang1, Y L Duan1, J Y Sun1
1Center for Clinical and Epidemiologic Research, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100029, China.
Zhonghua xin xue guan bing za zhi
|December 20, 2023
概括
中国成年人的血清脂蛋白 (a) [Lp(a) ] 水平通常保持稳定,但极限高度需要监测. 家庭病史,高血糖和他类药物的使用影响Lp (a) 随着时间的推移而变化.
科学领域:
- 心血管医学 心血管医学
- 临床化学 临床化学
- 流行病学 流行病学
背景情况:
- 血清脂蛋白 (a) [Lp(a) ]是动脉样硬化心血管疾病的独立风险因素.
- 了解Lp (a) 度的趋势和影响因素对于在不同人群中评估心血管风险至关重要.
研究的目的:
- 为了研究在中国社区队列中血清Lp(a) 水平的纵向变化.
- 确定与Lp (a) 度在五年内波动相关的关键因素.
主要方法:
- 一项前性队列研究,涉及1,955名中国成年人.
- 在基线 (2002年) 和随访 (2007) 测量出的血清Lp (a) 度.
- 多变量后勤回归分析以确定影响Lp变化的因素.
主要成果:
- 大多数参与者保持了他们的基线Lp(a) 度类别 (<30.0 mg/dl,30.0-49.9 mg/dl,或≥50.0 mg/dl).
- 临界高Lp(a) (30.0-49.9 mg/dl) 的个体显示37.0%的水平向更高水平的进展,55.4%保持在这个范围内.
- 患有心血管疾病的家族病史,禁食血糖升高以及使用降脂药物是Lp (a) 变化的显著预测因素.
结论:
- 在中国成年人中,血清Lp (a) 度在五年内往往保持稳定.
- 对于边界高水平的个体,特别是患有心血管疾病风险因素 (如家族病史,高血糖症或他类药物使用) 的个体,建议进行重复的Lp (a) 测试.
相关概念视频
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
164
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
164
01:31Lipid-derived Compounds in the Human Body
4.4K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.4K
01:29Cholesterol: Significance and Regulation
551
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
551
01:24Overview of Lipid Metabolism
1.6K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.6K
01:18Lipids: Dietary Sources and Requirements
745
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
745