口服酸盐补充剂改善了COPD的心血管风险标志物:ON-BC,一个随机对照试验
Ali M Alasmari1,2, Abdullah S Alsulayyim1,3, Saeed M Alghamdi4
1National Heart and Lung Institute, Royal Brompton Campus, Imperial College London, London, UK.
The European respiratory journal
|December 20, 2023
概括
从甜菜汁中补充酸盐改善了COPD患者的血压,内皮功能和运动能力. 这些好处持续了12周,这表明在这个人群中管理心血管风险的有希望的治疗选择.
科学领域:
- 心血管生理学心血管生理学
- 肺部医学 肺部医学
- 营养科学 营养科学
背景情况:
- 短期研究表明,饮食中酸盐 (NO3-) 可能改善心血管健康.
- 慢性阻塞性肺病 (COPD) 患者的长期影响和疗效尚不清楚.
- 富含酸盐的甜菜汁 (NR-BRJ) 是一种方便的酸盐来源.
研究的目的:
- 研究NR-BRJ对稳定的COPD患者心血管风险概况的持续影响.
- 评估NR-BRJ对血压 (BP),内皮功能和运动能力的影响.
- 评估12周NR-BRJ补充剂的安全性和有效性.
主要方法:
- 一项随机,双盲,安慰剂对照试验 (ON-BC) 涉及稳定的COPD患者,其心血压升高 (SBP).
- 参与者每天接受70毫升NR-BRJ (400毫克NO3-) 或酸盐减弱的安慰剂,持续12周.
- 主要终点是家庭SBP的变化;次要结果包括6分钟步行距离 (6MWD) 和内皮功能测量 (RHI,AIx75).
主要成果:
- 与安慰剂相比,NR-BRJ显著降低了SBP (-4.5 mmHg).
- 在6MWD (30.0m),反应性高血压指数 (RHI,0.34) 和增强指数 (AIx75,-7.61%) 中观察到改善.
- 这些对血压,内皮功能和运动能力的积极影响在整个12周的研究期间持续存在.
结论:
- 通过甜菜汁长期服用酸盐补充剂有效降低COPD患者的血压.
- 补充NR-BRJ与改善内皮功能和增强运动能力有关.
- 甜菜汁代表了一种可行的营养策略,可以减轻COPD患者心血管风险.
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