对成年精神分裂症皮质厚度减少的元分析
Shilin Sun1, Shu Xiao1, Zixuan Guo1
1From the Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China (Sun, Xiao, Guo, Tang, Huang, Wang); the Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, China (Sun, Xiao, Guo, Gong, Tang, Huang, Wang); the Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Gong).
Journal of psychiatry & neuroscience : JPN
|December 20, 2023
概括
这项元分析发现,精神分裂症患者,特别是慢性精神分裂症患者的下额前环,胰岛和上额环的皮质厚度减少.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
背景情况:
- 之前对精神分裂症的表面形态测量研究显示皮质厚度变化不一致.
- 需要进行全脑元分析,以提高识别这些变化的空间准确性.
研究的目的:
- 在成年精神分裂症患者中进行皮质厚度变化的全脑元分析.
- 为了比较第一期和慢性精神分裂症患者与健康对照.
主要方法:
- 对25项研究 (33个数据集) 的元分析,使用基于种子的d映射与对象图像的变量 (SDM-PSI).
- 包括2008年精神分裂症患者和2004年健康对照.
主要成果:
- 患有精神分裂症的患者表现出右下额头 (IFG) 和延伸到上性 (STG) 的双边胰岛的皮质厚度下降.
- 慢性精神分裂症患者的右侧胰岛和右侧IFG的厚度减少.
- 与对照组相比,在第一发精神分裂症患者中没有发现显著差异.
结论:
- 在成年精神分裂症患者,特别是慢性疾病患者中,建议在IFG,insula和STG中强大减少皮质厚度.
- 这些发现提供了对精神分裂症病理生理学的见解.
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