在精神分裂症中异常的半球间功能合作遵循神经递质配置文件
Kongliang He1, Qiang Hua1, Qianqian Li1
1From the Affiliated Psychological Hospital of Anhui Medical University, Hefei, China (He, A. Wang); the Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China (He, Hua, Yao, Sun, L. Wang, Ji, K. Wang); the School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China (He, Zhang, Yang, Xu, A. Wang, Ji, K. Wang); the Hefei Fourth People's Hospital, Hefei, China (He, A. Wang); the Anhui Mental Health Center, Hefei, China (He, A. Wang); the Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, China (Li); the Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China (Hua, Li, Zhang, Yang, Xu, Sun, L. Wang, Ji, K. Wang); the Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China (Hua, Li, Zhang, Yang, Xu, Sun, L. Wang, Ji, K. Wang); the Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China (K. Wang); and the Anhui Institute of Translational Medicine, Hefei, China (K. Wang).
精神分裂症患者表现出改变的半球间合作,特别是在额叶,与症状严重程度和疾病持续时间有关. 这些大脑连接的差异可能涉及神经递质系统功能障碍.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 半球间的合作是大脑的一个关键功能.
- 精神分裂症与半球间合作缺陷有关.
- 以前的方法受到半球对称性假设的限制.
研究的目的:
- 通过使用一种新的,不对称无偏的指数,研究精神分裂症中半球间合作缺陷.
- 探索这些缺陷与临床症状和神经递质系统之间的关系.
主要方法:
- 多模式MRI用于86名精神分裂症患者和86名健康对照人群.
- 构建了功能性同位素声 (CFH) 地图之间的连接.
- 研究了与症状得分和神经递质密度的相关性.
主要成果:
- 精神分裂症患者在额叶和特定转移中显示出明显较低的CFH,在尾状核中显示出较高的CFH.
- 观察到额叶功能连接性减少.
- 异常的CFH与阳性症状得分和疾病持续时间相关.
- 在空间上,CFH异常与多巴胺,血清素和乙胆载体密度有关.
结论:
- 半球间合作的区域异常可能是精神分裂症症状的基础.
- 这些大脑连接性改变可能与神经递质系统功能障碍有关.
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