代谢综合征和乳腺癌风险
Amira M Mohammed1, Hosney B Hamed2, Maisa K Noaman3
1Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Journal of the Egyptian National Cancer Institute
|December 20, 2023
概括
代谢综合征显著增加了埃及的乳腺癌风险. 改变生活方式以预防或逆转代谢综合征可以减少疾病负担.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 埃及对代谢综合征和乳腺癌风险的数据有限.
- 调查代谢综合征和乳腺癌之间的关联对于该地区的公共卫生至关重要.
研究的目的:
- 调查代谢综合征及其各个组成部分与乳腺癌风险之间的关联.
- 确定在埃及乳腺癌患者和对照组中代谢综合征的流行率.
主要方法:
- 一项涉及112例乳腺癌病例和112个年龄匹配对照的病例控制研究.
- 收集的数据包括人口,临床,人类特征和血液样本,以评估代谢综合征成分.
主要成果:
- 总体代谢综合征的患病率为42.9%,病例为57.14%,对照病例为28.6% (OR 3.33).
- 较高的BMI,高的禁食血糖,高血压,高的甘油三和低的HDL-C与乳腺癌有显著的关联.
- 一个线性趋势显示,乳腺癌患者的BMI较高 (p < 0.001).
结论:
- 代谢综合征及其组成部分与乳腺癌的风险增加有关.
- 社区对代谢综合征预防/逆转的认识和生活方式的改变可能会减轻乳腺癌发病率.
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