生殖因素,荷尔蒙干预和胃癌风险在胃癌聚合 (StoP) 项目中的生殖因素,荷尔蒙干预
Minkyo Song1, Harindra Jayasekara2,3,4, Claudio Pelucchi5
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Cancer causes & control : CCC
|December 20, 2023
概括
生殖因素和更年期激素治疗 (MHT) 可能会降低女性的胃癌风险. 更长的生育时间和MHT使用与较低的胃癌发病率有关,支持与激素相关的保护作用.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 生殖健康 生殖健康
背景情况:
- 胃癌的发病率在男性中更高,这表明激素在女性中可能起着保护作用.
- 胃癌聚合 (StoP) 项目联盟研究了与激素相关的对胃癌风险的影响.
研究的目的:
- 调查和量化女性生殖因素,更年期激素治疗 (MHT) 和胃癌风险之间的关联.
- 为了确定与激素相关的因素是否会影响不同亚型的胃癌风险.
主要方法:
- 在七个国家的11项研究中,对2,084例胃癌病例和7,102例对照病例的数据进行了元分析.
- 随机效应的元分析被用来估计概率比率 (ORs) 和95%置信区间 (CI).
主要成果:
- 生育时间≥40年与胃癌的风险降低25%有关 (OR=0.75).
- 使用MHT的绝经后妇女显示胃癌风险降低:使用过 (OR=0.73),5-9年 (OR=0.53),和≥10年 (OR=0.71).
- 这些关联在解剖学和组织学胃癌亚型中是一致的.
结论:
- 研究结果支持这样一个假设:生殖因素和MHT使用可能会降低女性的胃癌风险.
- 进一步的研究应探讨更年期前和更年期后妇女的荷尔蒙影响,并调查潜在的生物机制.
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