红细胞膜脂肪酸和肠道细菌在与肥胖相关的认知功能障碍中的关联
Tong Zhao1, Hongying Huang1, Jinchen Li1
1School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, People's Republic of China.
AMB Express
|December 20, 2023
概括
肥胖和认知障碍通过脂肪酸和肠道细菌联系在一起. 在认知衰退的肥胖个体中,较高的n-6/n-3多不和脂肪酸比率可能会影响肠道菌群和大脑功能.
科学领域:
- 神经科学是一个神经科学.
- 代谢过程中的代谢.
- 微生物学 微生物学
背景情况:
- 肥胖是认知障碍和痴呆症的重要危险因素.
- 肠道微生物群通过肠-大脑轴在认知功能中发挥着至关重要的作用.
- 脂肪酸与肥胖和神经健康有关.
研究的目的:
- 研究脂肪酸概况,肠道微生物群和肥胖个体的认知功能之间的关系.
- 阐明脂肪酸通过肥胖的肠道微生物群调节来影响认知功能的机制.
主要方法:
- 在肥胖参与者的认知功能评估.
- 红细胞膜脂肪酸组成的分析.
- 肠道微生物群的概况和与脂肪酸和认知评分的相关性分析.
主要成果:
- 与认知障碍 (MCI) 的肥胖个体相比,与认知正常的肥胖个体相比,红细胞膜中的多不和脂肪酸 (PUFA),酸 (C18: 2 n-6),酸 (C20: 4 n-6) 和n-6/n-3比率较高.
- 在MCI组中观察到较低的α-烯酸水平 (C18:3 n-3).
- 肠道细菌Coriobacteriales_Incertae_Sedis与C20:4 n-6和n-6PUFA正相关,与认知评分负相关.
结论:
- 红细胞膜中的n-6/n-3PUFA比率升高可能会通过炎症途径导致肥胖引起的认知损伤.
- 这些脂肪酸失衡也可能改变肠道微生物群的组成,进一步影响肥胖患者的认知功能.
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