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相关实验视频

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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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通过可穿戴的自动供电微针贴片增强深层黑色素瘤治疗.

Chenyuan Wang1, Guangqin He1,2, Huanhuan Zhao1

  • 1Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.

Advanced materials (Deerfield Beach, Fla.)
|December 20, 2023
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概括

这项研究引入了一种自动供电的微针 (MN) 贴片,配有灵活的 triboelectric 纳米发电机 (F-TENG),用于增强向深层瘤的药物输送. 综合系统在治疗小鼠深层黑色素瘤方面表现出卓越的疗效.

关键词:
坦格 (TENGENG) 是一个非常重要的东西.这是一种根深蒂固的黑色素瘤.离子化是一种离子化.微针是一种微针.通过皮肤传递药物.

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科学领域:

  • 生物医学工程 生物医学工程
  • 纳米技术纳米技术
  • 药物输送系统 药物输送系统

背景情况:

  • 对深层瘤的有效治疗需要通过透皮系统改善药物透.
  • 现有的微针 (MNs) 和离子泳技术面临着诸如皮肤抵抗力和电力需求等挑战,限制了深度瘤治疗.
  • 需要可穿戴的,自动供电的系统来克服对深层瘤的透皮药物输送的局限性.

研究的目的:

  • 开发一种可穿戴的,自动供电的微针 (MN) 贴片,与灵活的 triboelectric nanogenerator (F-TENG) 集成,用于先进的深层瘤治疗.
  • 通过克服皮肤屏障挑战,提高通过皮肤递送药物的效率,以准深层瘤.

主要方法:

  • 制造一个可穿戴的,自动供电的MN贴片,其中包含一个灵活的 triboelectric纳米发电机 (F-TENG).
  • 微针 (MNs) 是用水溶性材料制成的,负电荷的pH响应纳米粒子 (NP) 装载有治疗药物.
  • 在患有深层黑色素瘤的小鼠模型中评估集成的MN贴片系统.

主要成果:

  • F-TENG利用机械运动产生电能,为MN补丁提供动力.
  • 集成的MN贴片使治疗性NP能够深入皮肤,在酸性瘤微环境中迅速释放药物.
  • 与单独使用MN贴片相比,单次使用集成的MN贴片在抑制深部黑色素瘤方面表现出更高的治疗效果.

结论:

  • 使用F-TENG开发的可穿戴,自动供电的MN贴片为先进的深层瘤治疗提供了有前途的方法.
  • 这项技术有效地提高了通过皮肤向深部瘤部位的药物输送,克服了以前的局限性.
  • 该系统显示了治疗位于深部部位的瘤的显著潜力,改善了治疗结果.