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美国成年人联合暴露于二氧化物和关节炎之间的关联:一个横截面研究

Qi Meng¹, Yi Wang^2,3, Tao Yuan¹

¹Department of Joint Surgery, Shandong Provincial Hospital, Shandong University, Jinan, 250012, Shandong, China.

Environmental science and pollution research international

|December 20, 2023

概括

暴露于二氧化和二氧化类化合物 (DLCs) 与关节炎风险增加有关. 聚二156 (PCB156) 被确定为组合暴露分析中的重要贡献者.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
流行病学流行病学

背景情况:

二氧化物和类似二氧化物化合物 (DLC) 是持久性环境污染物,具有已知的人类健康风险.
关节炎是一种常见的疾病,具有复杂的病因因素,包括环境暴露.
了解DLCs对关节炎的影响对于公共卫生风险评估至关重要.

研究的目的:

调查暴露于12种特定的二氧化和DLC与关节炎患病率之间的关联.
为了确定与关节炎风险相关的个别DLC和联合暴露模式.
利用先进的统计模型进行可靠的暴露-反应评估.

主要方法:

利用了2001-2004年国家健康检查调查 (NHANES) 中1851名参与者的数据 (484人患有关节炎).
采用多变量逻辑回归,加权量子素和回归 (WQS) 和贝叶斯内核机器回归 (BKMR) 模型.
为多个共同变量进行调整,以隔离DLCs对关节炎的影响.

主要成果:

大多数单独的二氧化和DLC与关节炎有显著的积极关联,除了PCB66和hpcdf.
WQS回归显示,联合DLC暴露和关节炎之间存在显著的积极联系 (OR: 1.884,95%CI: 1.514-2.346).
PCB156成为联合暴露中最有影响力的原生物质,WQS中的最高权重和BKMR的后部包含概率 (PIP:0.987) 表明了这一点.

结论:

对二氧化和DLC的联合暴露与关节炎的风险增加有关.
PCB156是DLC和关节炎之间观察到的积极关联的关键贡献者.
这些发现强调了监测和减轻DLC暴露对于预防关节炎的重要性.

关键词:

关节炎是一种关节炎.贝叶斯核机器回归贝叶斯核机器回归二氧化物二氧化物是什么类似于二氧化物的化合物环境暴露环境暴露环境暴露权重的量化数量总和.

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