肝炎E病毒在患有慢性肝病的患者中的血清流行率
Lílian Rose Maia Gomes de Araújo1,2, Andrea Dória Batista3, Maria Rosângela Cunha Duarte Côelho4
1Postgraduate Program in Tropical Medicine, Center of Medical Sciences, Universidade Federal de Pernambuco (UFPE), Recife, Brazil. maia_lilian@hotmail.com.
概括
在3.08%的巴西慢性肝病患者中发现了E型肝炎病毒 (HEV) 抗体,特别是那些与猪接触并患有晚期疾病的患者. 这表明HEV可能会影响肝病的进展.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 在巴西慢性肝病 (CLD) 患者中,肝炎E病毒 (HEV) 的血清流行率未得到充分研究.
- 高血压病毒感染可能会加剧CLD的进展,增加肝硬化风险.
研究的目的:
- 为了确定在巴西的CLD患者中抗HEVIgG抗体的患病率.
- 为了确定人口统计学,风险因素和临床-实验室/超声波与抗HEV在CLD中的关联.
主要方法:
- 从2022年6月到2023年3月,对227名CLD患者进行横截面研究.
- 进行了临床评估,肝功能测试,抗HEV IgG,HEV-RNA测试和腹部上部超声波.
主要成果:
- 3.08%的患者 (7/227) 检测出抗HEV阳性 (HEV-RNA阴性).
- 抗HEV阳性与与猪接触相关联,妇,手掌红血,较低的血小板数量,较高的APRI/FIB-4分数和大.
- 肝硬化在37.9%的研究人口中存在.
结论:
- 在这个CLD队列中,抗HEV的患病率很低.
- 抗HEV更常见于暴露在猪和晚期肝病指标的患者,这表明在CLD进展中可能发挥作用.
相关概念视频
Hepatic Portal System
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is responsible...
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is responsible...
Diseases of the Liver and Gallbladder
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Hepatitis
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Hepatic Encephalopathy
DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...


