大脑MRI成像中的眼睛结构中的延迟加多泄漏:患病率和相关因素
Richard Olatunji1,2, Timothy Reynold Lim1, Blair Jones3
1From the Division of Diagnostic Neuroradiology (R.O., T.R.L., S.M., A.W.L., A.B., S.S.), Department of Medical Imaging, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, Ontario, Canada.
AJNR. American journal of neuroradiology
|December 20, 2023
概括
在对比剂施用后7天内,在6%的患者中发生了眼部结构 (GLOS) 中的加多泄漏. 较低的功能和更短的注射后时间间隔与GLOS有关,这表明潜在的分泌途径.
科学领域:
- 放射学 放射学是一门学科.
- 眼科医生 眼科 眼科
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 眼睛结构中的加多泄漏 (GLOS) 在FLAIR成像上呈现为高强度信号.
- GLOS与血眼屏障的破坏有关,特别是在缺血性中风患者中.
- 目前尚不完全了解GLOS的确切机制,但它可能是加多分泌的生理路径.
研究的目的:
- 在未经选择的患者队列中调查GLOS的流行情况.
- 为了确定与GLOS发生相关的因素.
主要方法:
- 对439名患者的回顾性分析,这些患者在加多基对比剂的7天内接受了脑部MRI.
- 收集临床,成像和实验室数据.
- 进行了描述性和后勤回归分析,以评估GLOS流行率和相关因素.
主要成果:
- 在6% (26/439) 的患者中检测到GLOS.
- 根据注射后的时间,GLOS患病率有所不同:24小时内12%,25-72小时后54%,73-120小时后31%,120小时后4%.
- 与GLOS相关的独立因素包括较低的估计膜过率 (eGFR) 和自加多注射以来较短的时间间隔.
结论:
- 在接受7天内加多对比剂的小百分比患者中观察到GLOS.
- GLOS与降低功能 (较低的eGFR) 和更短的注射后间隔有关.
- 虽然可能是一种生理性分泌途径,但需要进一步评估;对GLOS的认识有助于放射学解释.
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