Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

Search research articles

相关实验视频

Updated: Jul 7, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

超出平均值:α粒子分布和剂量异质性在骨转移性前列腺癌中

Nadia Benabdallah¹, Peng Lu^1,2, Diane S Abou¹

¹Mallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

|December 21, 2023

概括

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Extending Regression Without Truth to Integrate Ground-Truth Measurements for Evaluating Quantitative Imaging Methods with Patient Data.

Proceedings of SPIE--the International Society for Optical Engineering·2026

Same author

NGSE-Corr: A technique for objective clinical evaluation of quantitative-imaging methods without a gold standard.

IEEE transactions on medical imaging·2026

Same author

Stable Chelation of Zr-89 and Ac-225 with Dual Size-Selective Macrocyclic py<sub>2</sub>-macrodipa for <sup>225</sup>Ac/<sup>89</sup>Zr Paired Theranostics.

Inorganic chemistry·2026

Same author

Development of a Highly Effective Bifunctional Ligand 2E-C-NETA for Targeted Lu-177 Therapy: Synthesis, Radiolabeling, In Vitro Stability, and In Vivo Biodistribution.

ChemMedChem·2026

Same author

Exploratory FDG PET/CT Imaging in mCRPC Patients Treated with Sipuleucel-T ± IL-7: A Phase II Trial Subanalysis.

International journal of molecular sciences·2026

Same author

Phosphinate or Urea? Synthesis and Biological Evaluation of Prostate Specific Membrane Antigen-Targeted Fluorophores With Different Zinc-Binding Motif.

ChemMedChem·2026

在骨转移中,-223 ([223Ra]RaCl2) 的吸收在显微水平上是不均的. 这一发现对于理解α粒子治疗分布和优化患者治疗策略至关重要.

科学领域:

核医学是一种核医学.
在瘤学瘤学.
放射性药物疗法是一种放射性药物疗法.

背景情况:

由于高能量转移和局部剂量,α粒子发射器提供了强大的癌症疗法.
关于放射性药物在阿尔法粒子路径长度尺度上的分布的数据有限.

研究的目的:

确定[223Ra]RaCl2在骨转移性割耐性前列腺癌中近细胞尺度上的分布.
为了告知阿尔法粒子治疗的活性分布和剂量计算.

主要方法:

在[223Ra]RaCl2给药24小时后,从7名患者收集了活检样本和血液.
使用定量自辐射和微CT分析了[223Ra]活性.
进行了自动细分,组织病理记录和基于MIRD的剂量测量.

主要成果:

在患者样本和患者样本内观察到[223Ra]活性分布的显著差异.
在微观水平上,在低活性组织中确认了局部高活性区域.
发现异质的α粒子排放集中在骨组织接口,导致非均的吸收剂量配置.

结论:

患者数据显示,小规模骨转移中的[223Ra]吸收不均.

关键词:

223RaRa 223RaRa 223Ra 223Ra 223Ra 223Ra 223Ra 223Ra 223Ra 223Ra 223 自动辐射图像 (Autoradiography) 是一种自动辐射图像.活组织活检剂量测量方法剂量测量方法一个α粒子.

更多相关视频

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Published on: November 4, 2022

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

相关实验视频

Last Updated: Jul 7, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Published on: November 4, 2022

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

空间不均的剂量估计突出了改善患者结果的机遇和挑战.

这项研究是个性化阿尔法粒子放射性药物治疗的基本步骤.