冠心病重症患者的低体温和死亡率:从MIMIC-IV数据库的回顾性分析
Weiran Luo1, Lixue Cao2, Chuan Wang3
1The Six Clinical Medical School, Capital Medical University, Beijing, China.
European journal of medical research
|December 21, 2023
概括
低体温或低体温会增加冠状动脉心脏病 (CHD) 严重病患者的死亡风险. 即使是温度的轻微下降也与更高的住院,28天和90天死亡率有关.
科学领域:
- 临界护理医学 临界护理医学
- 心脏病学 心脏病学
- 热调节 热调节 热调节
背景情况:
- 患有冠心病 (CHD) 的重症患者经常经历温度调节失调.
- 了解体温对这一群体结果的影响对于改善患者护理至关重要.
研究的目的:
- 调查低体温 (低体温) 和慢性心脏病重病患者的死亡结果之间的关联.
- 在这个患者群体中量化与不同体温范围相关的死亡风险.
主要方法:
- 来自密集护理医疗信息中心 (MIMIC) -IV数据库的数据分析.
- 将患者分为三个体温组:≤36.5°C,36.6-37.4°C和≥37.5°C.
- 使用多变量考克斯回归,决策曲线分析 (DCA),限制立方线 (RCS) 和卡普兰-梅尔曲线进行综合分析,包括倾向得分匹配和子组分析.
主要成果:
- 共有8577名患者被纳入该研究.
- 低温 (≤36.5°C) 与正常热量相比,与增加的住院 (aHR 1.23,95% CI 1.01-1.49),28天 (aHR 1.38,1.19-1.61) 和90天 (aHR 1.36,1.19-1.56) 的死亡率显著相关.
- 每降低1°C的体温都与1年调整后的生存率下降14.6%相关.
结论:
- 低体温是一个独立的风险因素,增加了冠心病的危急病患者的死亡率.
- 这些发现强调了温度监测和管理在这个脆弱的患者群体中的重要性.
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