PRESERFLO MicroShunt植入与用于初级开角青光眼的轨道切除术相比:为期两年的随访研究
Pascal Aurel Gubser1, Valentin Pfeiffer1, Simon Hug1
1Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Eye and vision (London, England)
|December 21, 2023
概括
在两年时间内,PRESERFLO MicroShunt (PF) 植入物和trabeculectomy (TE) 有效地降低了眼内压力 (IOP),并减少了在开放角青光眼中使用药物的数量. 在这两组中,视网膜神经纤维层 (RNFL) 厚度在手术后下降.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 手术干预 手术干预
背景情况:
- 主要开角青光眼 (POAG) 的管理需要有效的眼内压力 (IOP) 降低.
- 轨道切除术 (TE) 是一种传统的玻璃眼外科手术,而PRESERFLO MicroShunt (PF) 植入是一种较新的替代方案.
- 对比这些程序的中期疗效对于临床决策至关重要.
研究的目的:
- 在POAG患者中,比较PF MicroShunt植入与TE的中期疗效.
- 评估功能 (视野) 和结构 (RNFL厚度) 参数的纵向变化.
- 评估每次手术后的内膜压力降低和药物使用情况.
主要方法:
- 对104只眼睛 (TE) 和83只眼睛 (PF) 进行了回顾性比较研究,随访时间至少为两年.
- 评估基线和手术后的内膜压力,内膜压力降低药物的数量,视野平均缺陷 (MD) 和外皮皮质视网膜神经纤维层 (RNFL) 厚度.
- 使用光学连贯断层扫描 (OCT) 进行RNFL厚度测量.
主要成果:
- 在两年内,TE和PF都显著降低了内血压和内血压降低药物的数量 (大多数措施的P<0.001).
- 平均内血压从基线下降到11.37 mmHg (TE) 和15.50 mmHg (PF).
- 视野MD在两组中保持稳定,但随访期间RNFL厚度在TE和PF组中呈现持续下降.
结论:
- 在降低IOP和减少药物需求方面,PRESERFLO MicroShunt植入证明了与带切除术相比较的中期疗效.
- 尽管视野稳定,但在手术后的两个手术组中都观察到RNFL厚度的逐渐减少.
- 可能需要进一步的研究来了解这些干预措施的长期结构影响.
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