结肠癌中瘤大小的预后值-较小更好?
Yan Meng1,2, Bingyan Wang1,2, Hsinyi Lin1,2
1Department of General Surgery, Peking University Third Hospital, Beijing, China.
The American surgeon
|December 21, 2023
概括
瘤大小会影响结肠癌的生存率. 在IIA阶段的小 (<3.5厘米) 和大 (≥5厘米) 瘤中,微卫星稳定性结肠癌与较差的无病生存率相关,以及与癌症相关的特定纤维细胞标志物.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 瘤微环境 瘤微环境
背景情况:
- 结肠癌中瘤大小的预后意义受到争论.
- 了解影响结肠癌预后的因素对于患者的治疗结果至关重要.
研究的目的:
- 研究结肠癌患者瘤大小和预后之间的相关性.
- 探索瘤大小,不匹配修复状态和瘤微环境之间的关系.
主要方法:
- 对491名结肠癌患者的临床病理学数据的分析.
- 瘤大小与预后的相关性分析,不匹配修复状态和瘤微环境标记.
- 评估转林 (TAGLN) 表达作为癌症相关纤维细胞 (CAFs) 的标志物.
主要成果:
- 在IIA阶段的微卫星稳定 (MSS) 结肠癌中,瘤<3.5厘米和≥5厘米与中等尺寸 (3.5-5厘米) 相比,无病生存率 (DFS) 更差.
- 无论是小 (<3.5厘米) 还是大 (≥5厘米) 瘤大小,在IIA阶段的MSS结肠癌中都独立预测了较差的DFS.
- 在CAF中高转林 (TAGLN) 表达是减少DFS的独立预测因子,并与较小的瘤大小有关.
结论:
- 瘤大小是IIA阶段MSS结肠癌的显著预后因素,两种极端 (<3.5厘米和≥5厘米) 与减少DFS相关.
- 在这个患者群体中,TAGLN表达CAF的丰富与较差的DFS和较小的瘤大小相关.
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