来自Urtica triangularis亚种的抗BPH基. 皮纳蒂菲达 (手 - 马兹) 这就是C.J.Chen
Qing Fu1, Dongliang Xiao1, Nan Jiang1
1College of Life and Health, Dalian University, Dalian, China.
Natural product research
|December 21, 2023
概括
从三角疹 (Urtica triangularis) 发现了一种新的干素,并对抗良性前列腺增生 (BPH) 的活性进行了测试. 化合物4与费纳斯特相比显示出更高的疗效,表明BPH治疗的潜力.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 药用化学 医学化学
背景情况:
- 良性前列腺增生症 (BPH) 是老年男性常见的疾病.
- 自然产品是BPH潜在治疗剂的丰富来源.
- 疹物种传统上用于各种疾病.
研究的目的:
- 从Urtica triangularis亚种中分离和描述化合物. 皮纳提菲达. 在这里.
- 评估隔离化合物的抗BPH活性.
- 通过对II型5α-reductase进行对接研究来研究作用机制.
主要方法:
- 使用染色学技术分离和净化类化合物.
- 使用质谱和光谱分析 (NMR等) 阐明结构. ) 的情况.
- 在BPH-1细胞的体外细胞毒性测定和在分子对接.
主要成果:
- 一种新型的原体, (-) - 银-9-O-β-葡萄皮化物 (1),与八种已知的原体一起被确定.
- 化合物4表现出显著的抗BPH活性 (IC50 = 79.75 ± 3.68 μM),表现优于费纳斯特 (IC50 = 91.8 ± 3.74 μM).
- 化合物1,2,和5表现出适度的抗BPH活性.
结论:
- 疹三角子子种子. 皮纳提菲达是一种具有抗BPH潜力的生物活性基素的来源.
- 化合物4是进一步开发作为抗BPH治疗药物的有希望的候选者.
- 这项研究为探索基素作为治疗BPH的新药提供了基础.
更多相关视频
07:16Preparation of Gynura bicolor DC samples for High-Resolution Tandem Mass Spectrometry
Published on: February 2, 2024
587
07:36Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
Published on: December 23, 2022
1.5K
相关概念视频
01:17Drugs for Treatment of Diarrhea-Predominant IBS
179
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
179
01:21Drugs for Treatment of Constipation-Predominant IBS
176
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
176