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感觉运动皮层和亚体体核对单手和双手手动的不同贡献
Christina M Merrick1, Owen N Doyle2, Natali E Gallegos2
1Department of Psychology, University of California Berkeley, Berkeley, CA 94720, United States.
Cerebral cortex (New York, N.Y. : 1991)
|December 21, 2023
概括
深度大脑刺激 (DBS) 可以通过双边参与下丘脑核 (STN) 来改善运动功能,该核集成上下文,与显示横向活动的感觉运动皮质 (SMC) 不同.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 帕金森病研究 帕金森病研究
背景情况:
- 在亚thalamic核 (STN) 的单边深脑刺激 (DBS) 往往导致双边运动改善在帕金森病患者.
- 这种双边效应背后的神经机制仍然不完全理解.
研究的目的:
- 为了研究传感运动皮质 (SMC) 和STN中的神经活动如何编码手部运动.
- 为了确定这些区域内的ipsilateral和contralateral手的代表性重叠程度.
- 探索任务上下文 (单手 vs.双手) 如何影响SMC和STN中的神经表示.
主要方法:
- 收集了来自帕金森病患者的SMC和STN在各种手动过程中的并行神经记录.
- 采用交叉验证的电极智能编码模型将电肌图 (EMG) 数据映射到神经信号中.
- 通过使用预测模型,评估手间概括和任务上下文效应.
主要成果:
- STN电极对两只手的运动进行了类似的编码,而SMC电极显示了相反的偏差.
- 在SMC和STN中,神经表示的双手间概括性很差.
- 与SMC相比,STN在单人工和双人工任务之间的神经活动中显示出更大的差异.
结论:
- 中小企业的活动是强烈的横向化和独立于背景的.
- STN将上下文信息与正在进行的运动行为整合在一起.
- 这些发现表明STN在调解双边运动控制中的作用,可能解释单边DBS的影响.
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