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希斯脱乙酶抑制使p53缺乏的B细胞前体急性淋巴细胞白血病对化疗敏感

Willem P J Cox1, Nils Evander1, Dorette S Van Ingen Schenau1

  • 1Princess Máxima Center for Pediatric Oncology, Utrecht.

Haematologica
|December 21, 2023
PubMed
概括

在复发的儿科急性淋巴细胞白血病 (ALL) 中TP53基因突变会导致耐药性. 基因组脱乙酶抑制剂罗米德素使抗化学疗法的ALL细胞敏感,提供了潜在的新治疗策略.

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