铜 (II) 和 (II) 复合物来源于含和的同结构双板基:合成,晶体结构和抗菌活性
Ke-Sheng Cao1, Ling-Wei Xue2, Qiao-Ru Liu3
1. 58051023@qq.com.
Acta chimica Slovenica
|December 21, 2023
概括
新的铜和希夫基复合物被合成并进行结构特征. 这些金属复合体对常见的细菌和真菌菌株表现出不同的生物活性.
科学领域:
- 协调化学 协调化学
- 材料科学 材料科学 材料科学
- 药用化学 医学化学
背景情况:
- 希夫基联体是协调化学中的多功能构建块.
- 金属复合体表现出多样化的生物活动,使它们成为抗菌剂的候选者.
研究的目的:
- 合成和表征新的单核铜 (II) 和 (II) 复合物.
- 为了研究这些金属复合物的结构性质.
- 评估合成复合物的抗微生物疗效,以对抗致病性细菌和真菌.
主要方法:
- 使用希夫基联体合成单核铜 (II) 和 (II) 复合体.
- 通过光谱学 (例如,UV-Vis,IR) 和元素分析进行结构性表征.
- 用X射线单晶衍射进行详细的结构确定.
- 对黄金葡萄球菌,大肠杆菌和白菌的生物活性测定.
主要成果:
- 四个单核复合物[CuLa] (1),[NiLa] (2),[NiLa]·CH3OH (2·CH3OH) 和[NiLb] (3) 被成功制备.
- X射线衍射证实了金属中心 (Cu (II) 和Ni (II)) 周围的正方形平面协调几何形状,涉及酸氧和胺.
- 这些复合物对所测试的细菌和真菌菌株表现出不同程度的生物活性.
结论:
- 该研究成功地合成和表征了新的铜和希夫基复合物.
- 结构分析显示了正方形平面协调,这对于这些类型的复合体是典型的.
- 生物评估提供了关于这些金属复合物的抗菌潜力的初步数据,需要进一步调查.
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