合成,特征和X射线晶体结构的Oxidovanadium(V) 复合物来源于N'-(2-Hydroxy-5-methylbenzylidene) -4-methylbenzohydrazide具有抗菌活性的复合物
Xue-Rong Tan1, Wei Li2, Meng-Meng Duan3
1. 1992189101@qq.com.
Acta chimica Slovenica
|December 21, 2023
概括
合成和表征了两种新的氧化 ((V) 复合物. 这些复合物对常见的细菌菌株表现出显著的抗菌活性,表明潜在的治疗应用.
科学领域:
- 无机化学 无机化学 有机化学
- 协调化学 协调化学
- 材料科学 材料科学 材料科学
背景情况:
- 复合物以其多样化的化学特性和生物活性而闻名.
- 酸连接物为金属离子提供了多功能协调可能性.
- 氧化瓦纳 ((V) 复合物由于其潜在的催化和药物应用而引起人们的兴趣.
研究的目的:
- 合成和表征新的双核和单核氧化复合物.
- 为了研究合成的复合物的结构特征.
- 评估合成的复合体对各种细菌菌株的抗菌潜力.
主要方法:
- 通过使用N'-(2-基-5-甲基利) -4-甲基基化物 (H2L) 和3-基-2-甲基-4-甲基 (HL') 连接物合成双核[V2O2L2 () ] (1) 和单核[VOLL'] (2) 氧化 () ]复合物.
- 使用IR,UV和1HNMR光谱学进行表征.
- 通过X射线单晶和粉末衍射进行结构确定.
主要成果:
- 两种新型氧化 ((V) 复合物的成功合成和完整表征.
- X射线晶体学证实了两个复合体中原子周围的八面体协调几何.
- 复合体2通过非经典的C-H∙∙∙O键形成一维链.
- 生物测试表明,对P.aeroginosa,S.aureus,B.subtilis和E.coli具有显著的抗菌活性.
结论:
- 合成的双核和单核氧化 ((V) 复合物具有有趣的结构性质.
- 这些复合体表现出有前途的广泛抗菌活性.
- 这些发现表明,有可能开发基于协调化学的新抗菌剂.
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