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开发和测试带有减少化潜力的跨导管心脏

Hellmuth Weich¹, Lezelle Botes², Anton Doubell¹

¹Division of Cardiology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Frontiers in cardiovascular medicine

|December 21, 2023

概括

使用脱细胞化牛心膜的新型透气管心 (THV) 显示,在绵羊中改善了耐用性和减少了化. 这些发现支持THV作为年轻患者需要心脏门置换的潜在解决方案.

科学领域:

生物材料科学生物材料科学
心血管外科心血管外科
再生医学是一种再生医学.

背景情况:

发展中国家的年轻患者通常需要心脏门手术,但缺乏持久的透气管心脏门 (THV) 选择.
目前的THV对年轻患者来说具有不够的耐用性,因此需要开发改进的材料.

研究的目的:

开发和评估使用两种类型的脱细胞牛心周叶片在一只绵羊模型中的新型跨导管心 (THVs).
将这些新型THV的耐用性,血液动力学性能和生物相互作用与行业标准进行比较.

主要方法:

使用三种组织类型制造的THV:固定在甲基 (GA) (0.05% DF,0.625%糖标准) 和非固定在GA (DE) 的脱细胞化牛心脏.
在九只幼羊的肺部位置植入THV180天,评估血液动力学性能,强度,结构和化.

主要成果:

工业标准的Glycar导致了一只动物心力衰竭,并显示增加了梯度,和化.
新的DE和DF门保持了正常的血液动力学,DF显示了减少的/化,而DE显示没有/化.
德组织表现为无活性的,没有宿主内生长,但保持了叶片的完整性和机械功能.

结论:

脱细胞化的牛心膜,特别是惰性DE组织,与标准的甲固定组织相比,提供了更好的耐用性和血液动力性能.
使用这些脱细胞化心周组织的新型THV对需要心脏门置换的年轻患者显示出有前途.
对THV中这些脱细胞化组织类型的进一步评估对于儿科和年轻成人群体是有必要的.

关键词:

塔维 (TAVI) 是一个古老的城市.石灰化是指化.脱细胞化的心脏周围.低剂量的谷物甲酸.羊类模型模型穿过导管的心脏门

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