消费人工甜味剂可能会改变十二指肠微生物群落的结构和功能
Ava Hosseini1, Gillian M Barlow1, Gabriela Leite1
1Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
iScience
|December 21, 2023
概括
消费非糖类甜味剂会改变肠道微生物群. 甜味剂减少了十二指肠多样性,改变了细菌组成,在便样本中观察到相反的效果.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 人类健康 人类健康 人类健康
背景情况:
- 之前的研究表明,非糖甜味剂 (NSS) 根据便样本影响肠道微生物组合.
- 便样本可能不完全代表整个胃肠道的微生物群.
研究的目的:
- 为了研究非糖类甜味剂消费对十二指肠光微生物群的影响.
- 为了比较十二指肠微生物组的变化与便微生物组的变化.
主要方法:
- 在食用非阿斯巴达姆非糖甜味剂 (NANS),仅食用阿斯巴达姆 (ASP) 和对照组 (CON) 的受试者中对十二指肠光微生物组的分析.
- 在一小部分参与者的便微生物组分析.
- 微生物多样性和相对丰度 (RA) 的比较.
- 十二指肠微生物代谢通路的预测.
主要成果:
- 与对照组相比,NANS消费者的十二指肠α多样性下降.
- 蛋白质细菌 (例如,Escherichia,Klebsiella,Salmonella) 的RA在十二指肠中较低,但在NANS和ASP组的便中增加.
- 在NANS消费者中改变的十二指甲状腺代谢途径包括多糖生物合成和D-银糖降解.
结论:
- 不含糖的甜味剂的消费显著改变了小肠微生物组的组成和功能.
- 在十二指肠观察到的微生物组变化不同于便样本中的微生物组变化.
- 需要进一步的研究来了解这些变化的全部影响.
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