在三级新生儿病房中对细菌学概况和抗生素图的回顾性审查
Philile F Buthelezi1, Fathima Naby1, Yashodhara Kannigan1
1Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, Faculty of Health Sciences, University of KwaZulu-Natal, Pietermaritzburg, South Africa.
Southern African journal of infectious diseases
|December 21, 2023
概括
新生儿败血症是一个主要问题. 这项研究发现,在南非的NICU中,格兰阴性细菌,特别是Klebsiella pneumoniae,对常见的抗生素 (如安培素和甘他素) 产生很高的耐药性.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 新生儿护理 新生儿护理
背景情况:
- 新生儿败血症是婴儿疾病和死亡的重要原因.
- 及时诊断和经验性抗生素治疗对于改善结果至关重要.
研究的目的:
- 确定格雷医院新生儿重症监护室 (NICU) 内的抗生素耐药性模式 (抗生素图).
- 提供数据,为新生儿败血症的实证抗生素治疗指南提供信息.
主要方法:
- 进行了一项回顾性描述性研究.
- 分析了2017年1月至2019年12月NICU中阳性微生物培养的数据.
- 包括所有样本地点的所有阳性培养物.
主要成果:
- 总共有1314个阳性生物被确定,晚发性败血症占主导地位 (89.3%).
- 格拉姆阳性生物 (53.7%) 比格拉姆阴性生物 (45.7%) 稍高一些.
- 克莱布西拉肺炎是最常见的格拉姆阴性分离物 (23.5%),对安比西林 (99%) 和仁素 (92%) 具有很高的耐药性.
结论:
- 血液培养是最常见的积极结果来源.
- 显著比例的孤立生物体对安培素和 gentamicin 呈现耐药性,这是该单位的第一线抗生素.
- 建议对培养结果进行持续监测,以评估当前抗微生物指南的有效性.
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