疾病发病时的年龄是否会影响免疫球蛋白A血管炎儿童的临床表现和结果?
Emine Nur Sunar Yayla1, Sevcan A Bakkaloğlu1
1Department of Pediatrics, Division of Pediatric Rheumatology, Gazi University Faculty of Medicine, Ankara, Türkiye.
Archives of rheumatology
|December 21, 2023
概括
诊断时的年龄会影响儿科免疫球蛋白A血管炎 (IgAV) 的临床结果. 年长的孩子可能会出现更多的紫外线,但较少的关节炎,年龄与脏和类固醇依赖性疾病有关.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 血管炎研究 血管炎研究
- 免疫学 免疫学 免疫学
背景情况:
- 免疫球蛋白A血管炎 (IgAV) 是最常见的儿童系统性血管炎.
- 了解影响IgAV表现和预后的因素对于有效管理至关重要.
研究的目的:
- 研究儿童IgAV患者诊断时的年龄和临床,实验室和预后特征之间的关系.
- 为了确定IgAV呈现和疾病过程中的与年龄相关的模式.
主要方法:
- 在2005年1月至2020年7月期间诊断的539名儿科IgAV患者的回顾性评估.
- 统变逻辑回归分析,以评估临床发现与诊断时的年龄之间的关系.
- 检查与脏干扰,类固醇依赖/耐药性疾病和复发相关的因素.
主要成果:
- 诊断时的年龄与紫外线有积极的关联,与关节炎有反向的关联.
- 脏干扰与诊断时的年龄较大 (OR=1.22),随访时间较长,没有先前感染和肠道干扰显著相关.
- 诊断时的年龄较大和随访时间较长与耐药性疾病有关;所有耐药患者都患有脏干扰.
结论:
- 诊断时的年龄和随访时间可能会影响脏干扰和耐火性或依赖于类固醇的IgAV的发展.
- 类固醇依赖性疾病可能与脏,肠道和阴囊的参与有关.
- 胃肠道干扰可能与儿科IgAV的疾病复发有关.
更多相关视频
12:21A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Published on: September 28, 2022
2.5K
07:50A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
15.9K
相关概念视频
Development of Immunocompetence
310
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
310
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
Immunodeficiency Diseases
945
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
945
Humoral Immune Responses
72.7K
Overview
72.7K
