对可生物降解食道支架的材料,应用和未来创新的全面审查
Yaochen Yang1,2, Yuanyuan Yang1, Zhipeng Hou2
1Department of Gastroenterology, Endoscopic Center, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang, China.
Frontiers in bioengineering and biotechnology
|December 21, 2023
概括
可生物降解的食道支架通过克服传统金属和塑料支架的局限性,为食道狭窄 (ES) 提供了改进的解决方案. 诸如药物释放能力和3D打印等创新有望为良性和恶性疾病提供更有效的治疗方法.
科学领域:
- 胃肠病学 胃肠病学
- 生物材料科学 生物材料科学
- 医疗设备工程 医疗设备工程
背景情况:
- 食道狭窄 (ES) 是由良性和恶性疾病引起的,通常通过内镜支架插入来管理.
- 目前的自扩展金属 (SEMS) 和塑料支架 (SEPS) 具有诸如迁移,复缩和在良性病例中需要切除等缺点.
- 临床需要改进食道支架材料和设计.
研究的目的:
- 提供当前可生物降解的食道支架材料及其应用的全面概述.
- 突出生物降解食道支架技术的研究局限性和创新.
- 提供对食道狭窄治疗的未来发展优先事项的见解.
主要方法:
- 对食道支架的可生物降解材料的科学文献的综述.
- 分析当前和新兴的食道支架技术,包括药物释放支架 (DES).
- 探索新的制造技术,如3D打印和先进材料,如水凝.
主要成果:
- 生物降解材料,如聚聚合物和合金,由于生物相容性和生物降解性,显示出有前途.
- 新型支架设计包括单向药物释放和抗迁移等功能.
- 像3D打印和水凝这样的新兴技术正在推动支架创新.
结论:
- 可生物降解的食道支架解决了传统支架的局限性,为改善ES管理提供了潜力.
- 目前正在进行的研究重点是药物泄漏能力和增强的功能特征,以实现精确和高效的治疗.
- 未来的方向包括对良性和恶性食道狭窄的临床应用,旨在改善患者的治疗结果.
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