对活跃克罗恩病患者的静止状态功能连接的检查
Gita Thapaliya1, Sally Eldeghaidy2,3,4, Shellie J Radford4
1Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
在活跃的克罗恩氏病 (CD) 中,休息状态功能连接 (rs-FC) 改变会影响认知和注意力网络. 这些大脑连接的变化与患者的疾病持续时间和腹痛严重程度相关.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 医疗成像医学成像
背景情况:
- 克罗恩氏病 (CD) 在各种大脑网络中表现出改变的静止状态功能连接 (rs-FC),形成独特的神经表型.
- 大多数先前的研究集中在缓解期的CD患者身上,对活跃疾病状态的数据有限.
研究的目的:
- 为了研究活跃克罗恩病患者的rs-FC变化.
- 为了将这些神经变化与疾病持续时间和腹部疼痛等临床参数相关联.
主要方法:
- 招募了25名活跃的CD患者和25名健康对照 (HC) 进行静止状态功能磁共振成像 (rs-fMRI).
- 通过高C反应蛋白,便calprotectin或成像/内镜证据来定义活性CD.
- 使用独立组件分析 (ICA) 和双回归分析了rs-fMRI数据.
主要成果:
- 活跃的CD患者表现出前额状网络 (FPN) 和视觉静止状态网络 (RSN) 的连接性增加.
- 在CD患者的突出网络,默认模式网络 (DMN) 和小脑网络中观察到连接性下降.
- rs-FC模式与腹痛严重程度和疾病持续时间相关.
结论:
- 活跃CD中改变的rs-FC涉及对认知,注意力,情绪和疼痛处理至关重要的网络.
- 这些神经变化可以作为克罗恩病中慢性炎症,疼痛和疾病严重性的生物标志物.
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