在娱乐性使用氧化后出现功能性维生素B12缺乏症的病例
Damien Leleu1,2, Damien Denimal1,2
1Department of Clinical Biochemistry, Dijon University Hospital, Dijon, France.
Biochemia medica
|December 21, 2023
概括
娱乐性氧化滥用可以通过非活化维生素B12引起神经损伤. 诊断是具有挑战性的,因为标准的维生素B12水平可能看起来正常,尽管功能缺陷.
科学领域:
- 神经学 神经学
- 毒理学 毒理学 毒理学
- 血液学 血液学 血液学
背景情况:
- 娱乐性氧化 (N2O) 使用是年轻人日益关注的公共卫生问题.
- 慢性N2O滥用会导致由于维生素B12不活化而导致严重的神经疾病.
- 维生素B12缺乏是N2O相关的神经损伤的一个关键因素.
研究的目的:
- 报告一种N2O诱导的维生素B12功能缺陷病例.
- 在疑似N2O滥用的情况下突出诊断挑战.
- 提高医疗专业人员对这一群体B12状态解释的认识.
主要方法:
- 一个22岁的女性有不明原因的意识丧失的案例报告.
- 临床检查宏细胞性贫血和高分段性中性粒细胞的迹象.
- 实验室检测包括血清叶酸,维生素B12,总同类半氨酸和甲基马龙酸.
主要成果:
- 患者出现了贫血和高分段中性粒细胞,但血清维生素B12和叶酸水平正常.
- 血清总同类半氨酸和甲基马龙酸的升高表明维生素B12功能受损.
- 患者病史显示慢性休性氧化消耗.
结论:
- 滥用氧化可以导致功能性维生素B12缺乏,模仿典型的缺乏症症状.
- 正常的血清维生素B12水平并不排除N2O滥用者的缺乏.
- 准确的诊断需要意识到N2O滥用,并考虑功能性B12标志物.
更多相关视频
14:52Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
Published on: January 13, 2018
11.0K
05:46A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
4.9K
相关概念视频
Vitamins
730
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
730
CNS Depressants: Alcohol and Nicotine
213
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
213
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
281
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
281
Minerals
314
Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
Major...
Major...
314
Bulimia Nervosa
85
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
85
